It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Lol....well you don't have your stats and goals and age and bf and how many cycles and all that up (I don't think, I'll check again) so its hard to give advice. Let me put up a cycle that would be for a second timer because first cycle advice is always, "learn the compounds one at a time so you know what is doing what and how you tolerate eacbh etc", test 1-12 at 500 on a long ester, adex on hand and proper pct. So a second cycle incorporating var might be, and this is a low ball for someone who wants var bad, ...cycle one; long etser E or C 1-12 300 mg per week split with var coming in week 5- 8 at 40 mg and then 9-12 at 80 mg. Adex on hand and proper pct. Cycle two low ball just so you have test on hand and get to use your var. 1-8 test prop 100 eod, var at 40 mg 1-4 and 80 mg 5-8 , adex on hand and proper pct. Those cycles will not cause everything to disappear slowly as pct ends as long as diet is dialed in. Pill munching is a nasty habit brother and next thing you know, because you can't keep your gains, you're muncjin pills all the time. Primo and var , just primo, just var, dbol.....the needle is not that bad and after you do it you will be so much happier with your gains and keeps that you will be glad you never started the pill habit. This stuff really is tough on the liver so the pin is always safer by far and then an oral once a year in moderation is one thing. You cn use the var but never be determine to use something just because you have it or because you got a good deal on it. Again, all that is hypothetical until we know you have ran a cycle and are old enough...even if not and you are going to do what you want, at least structure it right with a test only run first if it is your first cycle.